Dr. Marissa G. Noel: 2017 PFCS Achievement Award for Service to the Chemistry Profession

Dr. Marissa Garcia Noel has long been quietly working to the benefit of the Philippine Chemistry Community. She has been a regular member of organizing committees of the Philippine Chemistry Congress and most notably, has been an indispensable and trusted organizer to whom industry partners and exhibitors flock.  She efficiently headed the Ways and Means Committee of many local and international PCCs since 2001 while capitalizing on her reputation to influence industry people, raise funds and generate income for the PCC.  Likewise, she also rendered similar services to the Natural Product Society of the Philippines (NPSP).  She sat on the organizing committee of several NPSP National Conferences and was the lead local organizer/host of the December 2013 conference held at DLSU.

Dr. Noel is instrumental to the ratification of the Chemistry Law.  Marissa, together with siblings Representative Victoria Isabel G. Noel and Former Representative Florencio Gabriel G. Noel, helped the Integrated Chemists of the Philippines (ICP) and the Philippine Federation of Chemistry Societies (PFCS) by liaising and lobbying for the Chemistry Profession Act in the Philippine Congress and Senate.  After years of lobbying, dogged persistence and monitoring, the Chemistry Profession Act was signed into law by the Philippine President in 2015.  The new Chemistry Law regulates, modernizes and protects the practice of the Chemistry profession in the Philippines.

She is the former Chair of the Chemistry Department of De La Salle University where some of her primary responsibilities include revising and offering new curricular programs, mentoring graduate and undergraduate students, promoting food chemistry research, mentoring and training new faculty members and helping organize the DLSU Food Institute and the food chemistry laboratory at the DLSU Science and Technology Complex in Laguna.

Throughout her professional career, Dr. Noel has been competently and quietly pushing for the cooperative amalgamation of the academe, the chemical industries and the policy-making sectors of the country for the advancement of chemistry.

Dr. Noel hails from Tacloban, Leyte. She obtained her BS Chemistry from the University of San Carlos and briefly taught at the Divine Word University. She did her MS in Food Science at the University of the Philippines at Los Baños and worked as a research assistant at the Southeast Asian Regional Center for Graduate Studies and Research in Agriculture (SEARCA) and the Institute of Food Science and Technology. She later joined De La Salle University, and finished her PhD at Ateneo de Manila University under Dr. Fabian Dayrit.

Dr. Maribel G. Nonato: 2017 PFCS-Shimadzu Achievement Award for Research

Dr. Maribel G. Nonato obtained her doctoral degree in Organic Chemistry with specialization on Natural Products Chemistry from the University of Wollongong, New South Wales, Australia in 1993.  Upon her return to the University of Santo Tomas, Dr. Nonato resumed her research activities at the Research Center for the Natural Sciences (RCNS) were she pioneered research on the Phytochemistry and Biological Activities of Philippine grown species of the Genus Pandanus (Family Pandanaceae).  The main goal of the research is the discovery of novel or new bioactive secondary metabolites from the Genus Pandanus. It is the future goal of the project to develop the plants into herbal products.

Monocots are rarely tapped as source of bioactive secondary metabolites.  The Genus Pandanus is a monocot comprising of about 450species with about 20 species endemic to the country.  There were very limited works reported on Pandanus when Dr. Nonato started her work on the world of pandans in 1991.  An initial engagement was established with the late Dr. Benjamin Stone, the world renowned Pandanus botanist who was then working with the National Museum on a project focused on the inventory of Philippine medicinal plants.  Dr. Stone was delighted to hear of someone interested to work on the group of plants that feature prickled, fibrous and hard leaves.  Unfortunately, because of Dr. Stone’s untimely death while in the Philippines, the partnership did not prosper.  But that did not stop Dr. Nonato from continuing her passion to discover the virtues of the Genus Pandanus to add values on their known medicinal and handicraft uses.

The novelty of the Pandanus alkaloids merited an invitation to write a chapter on the book series “The Alkaloids:  Chemistry and Biology” in 2008 acknowledging the contribution of  Dr. Nonato to the Chemistry of Alkaloids. So far the study on Philippine grown Pandanus species revealed the presence of alkaloids in two Pandanus species, P. amaryllifolius and P. dubius.   Dr. Nonato’s research on the novel alkaloids of Pandanus earned her the 2006 National Research Council of the Philippines Achievement Award in Chemical Sciences.  To better understand the biogenesis of the Pandanus alkaloids which so far were found to be limited in two Pandanus species she conducted studies on the endophytic fungi thriving on the leaves of P. amaryllifolius.  The research led to the discovery of new secondary metabolites with new biological activities.  Neighboring countries like Malaysia, Indonesia and Thailand started to undertake similar researches on their Pandanus species. Biological studies on the Pandanus species reveled the potential of these plants as source of antimicrobials, antiviral, diuretics, antituberculars, antioxidants and anti-inflammatory agents.

Dr. Maribel G. Nonato is presently the Vice Rector for Research and Innovation at the University of Santo Tomas (UST), first female and lay person to assume the post since September 2014.  She had served the University of Santo Tomas as administrator in different capacities: Director of Research Center for the Natural Sciences, acting Assistant to the Rector for Research and Development, Dean of the College of Science and Assistant to the Rector for Research and Innovation.

Dr. Ramon S. del Fierro: 2017 PFCS-Unilab Achievement Award for Chemistry Education (Tertiary Level)

Ramon S. Del Fierro is currently an Assistant Vice President for Academic Affairs and Professor of Chemistry in University of San Carlos, Cebu City. His expertise and research interests include: Natural products Chemistry; Biochemistry, Chemical Toxicology; Bioassays; Chemical Education; Educational Administration and Leadership.

Mark Valentine P. Balanay: 2017 PFCS-Shimadzu Achievement Award for Chemical Industry

Mark Balanay used his chemical knowledge and skills to become a leader in Philippine Sinter Corporation, a major corporation in Cagayan de Oro. He has engaged in a wide range of activities, including operation & production, analytical laboratory management, research & quality assurance, and human resource management. He is also the company’s lead auditor for ISO 14001 & ISO 9001. Mark has likewise used his skills to guide and build up the chemistry community in northern Mindanao into an active and responsive organization. This mix of experience, competencies and commitment, including his dynamic interface with government, academe, industry, and scientific associations, makes him a well-rounded leader.

He obtained his BS Chemistry Degree at Xavier University-Ateneo de Cagayan as a DOST scholar. He obtained a MA Management Degree major in Environmental Management at Liceo de Cagayan University and a BS in Secondary Education at the Mindanao University of Science and Technology.

Janeth Morata-Fuentes: 2017 PFCS Achievement Awardee for Chemistry Education (Secondary Level)

Ms. JANETH MORATA-FUENTES is a special science teacher at the Philippine Science High School-Eastern Visayas Campus in Palo, Leyte. She teaches Chemistry and handles Science &Technology Research. She graduated from the University of the Philippines (Diliman) with a degree of Bachelor of Science in Education (Chemistry).  She took her Master of Education (Teaching and Curriculum Studies) at the University of Sydney (New South Wales, Australia) where she graduated with merit. She is currently a PhD (Chemistry Education) student at the UP Open University.

As a teacher, Janeth passionately mentors gifted students of Pisay. In recognition of her excellence in teaching, she was granted the Metrobank Foundation Outstanding Teacher Award in 2010 – the youngest teacher recipient of this career award. That same year, the PSHS Foundation’s Dr. Cleofe Bacungan Endowment Fund accorded her the honor of the Natatanging Guro (Natural Sciences Cluster) Award, in acknowledgment of her meritorious teaching service.  She was also conferred the highest award for Civil Servants, the Presidential Lingkod Bayan Award in 2011 in recognition of her efforts to improve quality of life by conducting activities promoting science and technology research and advancing science education. She was awarded in 2012 by the Academy of Singapore Teachers (Ministry of Education) the Outstanding Educator in Residence placement, training Chemistry teachers and involving herself in consultancy work with school administrators and master teachers.

As a research teacher, she mentored students who were awarded grand prizes in the Intel International Science and Engineering Fair, earning her a citation for Outstanding Contribution as Research Adviser. She also leads conduct of significant researches such as environmental studies of bodies of water in Leyte, exploration of natural products from marine sources and finding ways to mitigate harmful algal blooms.

Janeth is not just involved in teaching and research. Recently, she served as Project Leader of the PSHS System’s Curriculum Review and Materials Development Project which oversaw the development and revision of the PSHS curriculum to align it with the K-12 program of the government and meet its mission of providing a special science curriculum for gifted students. Aside from this, she also spearheaded the PSHS-Meralco National Science Fair for two years which later became the Philippine International Science Fair. The said fairs featured scientific studies from all PSHS campuses and from international participants. She also served as National Coordinator of the Upgrading Program: Learning Institute for Teachers, a nationwide program of PSHS which trained teachers in Science, Math and English in preparation for the rollout of the K-12 curriculum.

Janeth also busies herself with book writing projects and is co-author of a book in Integrated Science. She is also invited as resource person in various teacher trainings where she shares her expertise in teaching, curriculum development and pedagogy.

Despite these achievements, Janeth remains humble and grounded and is a most loyal friend to a select group of people. She often jokes that she will never win an award for exemplary mom but she might win one for trying very hard. She spends downtime with her children, Earendil and Earwen, who serves as balm to her often tired self and who has banned her from doing any cooking for them.

Acceptance Speech of Mark Valentine P. Balanay–2017 PFCS-Shimadzu Achievement Award for Chemical Industry

Thank you to PFCS for honoring me with this prestigious award. Never in a million years would I have predicted that I would have been recognized for any Chemistry-related achievement but with great humility and honor, I accept this award fully acknowledging my family, mentors, colleagues, and friends who have helped me in making this recognition possible.

I would like to give thanks to many institutions who helped me in my journey. I especially thank my employer, Philippine Sinter Corporation for allowing me to grow professionally and personally in the past seventeen years. I would also like to mention the five Chemistry Departments from the five universities which are the pillars of Chemistry instruction and of the ICP-KKP Local Chapter in Northern Mindanao, namely: Xavier University-Ateneo de Cagayan, University of Science & Technology in Southern Philippines, Central Mindanao University, Mindanao State University Main in Marawi, and MSU-Iligan Institute of Technology. Knowing and working with all passionate and dedicated teachers, colleagues and friends in these great chemistry departments made me feel so proud of this chosen profession.

I would also like to acknowledge the support of ICP – headed by Dr. Fabian M. Dayrit and Ms. Edna C. Mijares. Thank you for your support to the local chapters and I express my great appreciation for your effort on the passing of the new Chemistry law which I firmly believe will not only benefit the chemists but the Philippine Industry in general.

Part of the pleasure of receiving this award is the opportunity to reminisce – especially of my career in the past seventeen years, and the opportunity and honor of learning from great chemistry professionals in all those years.

I finished BS Chemistry in 2000 at Xavier University in Cagayan de Oro. I started working in Philippine Sinter Corporation two weeks after I passed the licensure exams, and still am connected with the same company up to now. I was first assigned as a QA shift chemist – experiencing the sacrifices which among others involve working during Christmas or New Year’s Eve. Later, I then assumed the manager role for various positions including Quality Assurance, Production, New Business Division and even the Human Resource and General Affairs – on top of my concurrent role as a Pollution Control Officer and Head of the Integrated Management System Internal Audit.

In every position that I am assigned in, I always use my knowledge and training in Chemistry even in the area of Human Resource Management – relying only on accurate and precise data gathered using repeatable standard procedures before coming up with critical decisions. It was in this discipline that I successfully nurtured many quality improvement teams to drive innovations in the company.

As an QA analyst way back in year 2000, I was inspired by industrial chemists – including the late Mary Zayas of Resins Incorporated – an expert in synthetic resins and industrial adhesives who became my informal mentor in college and Dr. Romeo del Rosario – my professor in graduate school who is a well-respected Oleochemicals Industrial chemist and Chemistry Professor in Northern Mindanao – in sharing our unique and valuable experience in the industry especially to our Chemistry undergrads. This inspiration led me to accept in year 2006 a part-time teaching position at the University of Science & Technology in Southern Philippines where I teach Environmental Chemistry, Material Science and Environmental Management & Technology. Aside from my contribution to the company and the steel industry in general, I believe that this opportunity to mentor new generations of chemists is my proudest achievement by far.

I also believe that we in the industry should play a more active role in the improvement of the practice of chemistry in the regions. When I became President of ICP-KKP Regions X/XII/ARMM and CARAGA in year 2010, I solicited the active participation of my colleagues in the industry as we organized our semi-annual Regional Chemistry Congress and designed it to be more relevant to all stakeholders. Very successful were these regional congresses that in 2015, we were able to organize the very first and very successful Mindanao Chemistry Congress.

We in the industry see problems and opportunities from different perspectives and can offer solutions even to those outside the scope of the company’s operation. Many of us are perhaps sustaining the quality & environmental management systems, driving innovations, or leading our organizations. Our experiences in the diverse, flexible and dynamic organizations allow us to possess specialized competencies, unique knowledge and leadership & management skills that are needed in mobilizing people and in implementing programs to address problems especially those affecting the marginalized or threatening our planet’s sustainability.

To end, I once again give thanks to PFCS for acknowledging us – the chemists in the industry. To all my colleagues in the industry, may this award challenge us to contribute more to the science and society at large. Let us continue to be innovators, mentors and leaders. As I accept this award on your behalf, may we all be reminded that “it is our nature and perhaps destiny to discover more of the capacities of chemistry, but it is both a practical and a moral imperative that we do so with care, wisdom, gratitude, and awe”.

Ladies and gentlemen, thank you very much!

Mark Valentine P. Balanay is the recipient of the 2017 PFCS-Shimadzu Achievement Award for Chemical Industry. He delivered this speech during the awarding ceremony in the 32nd Philippine Chemistry Congress, Asturias Hotel, Puerto Princesa City, Palawan.

He is currently the Senior Manager of Sinter Department–Production Division, Philippine Sinter Corp. He used his chemical knowledge and skills to become a leader in Philippine Sinter Corporation, a major corporation in Cagayan de Oro. He has engaged in a wide range of activities, including operation & production, analytical laboratory management, research & quality assurance, and human resource management. He is also the company’s lead auditor for ISO 14001 & ISO 9001. Mark has likewise used his skills to guide and build up the chemistry community in northern Mindanao into an active and responsive organization. This mix of experience, competencies, and commitment, including his dynamic interface with government, academe, industry, and scientific associations, makes him a well-rounded leader.

Acceptance Speech of Janeth Morata-Fuentes–2017 PFCS Achievement Award for Chemistry Education (Secondary Level)

To our Guest of Honor, the officers of the different Chemistry Societies, participants to the Chemistry Congress, to everyone who are here, a good evening.

The study of chemistry has always fascinated me. There is wonder in transformations. There is beauty in explaining macroscopic phenomena by elucidating the motions of invisible particles. In this lifetime, I first knew about the atomic theory in a high school class. There were no direct evidences of its existence decades ago. Years into my teaching career, I encountered pictures of the surface of an atom. Imagine the excitement I felt then! It was the same excitement I felt when I read a journal article describing how carbon can make not just double and triple chemical bonds but quadruple bonds, too! There is a treasure trove of knowledge nowadays that opportunities for making lives better are within reach. Chemistry is at the center of all this.

I love it when I see the look of amazement on my students’ faces every time they encounter this seemingly magical world. I also love it when I see perplexed looks when they meet thought-provoking problems; or the aha moments they have every time hard concepts become less difficult. Chemistry is not always an easy discipline to tackle.

During my first few months as a university student, I had this recurring dream of chemical equations running after me. I’d be so panicked because I couldn’t balance them. My experience as a chemistry student included spending sleepless nights to understand concepts so as to pass exams. I am more empathetic to my students’ difficulties and failures because I have laboured in the study of this discipline too. It is easier for me to spot confusion, frustration and panic among young faces, because I’ve gone through these emotions myself. In my life as an educator, I have always tried to teach my kids perseverance and resilience. The study of the sciences may not be a walk in the park, but the joy in discovery is always worth the hard work and the uncertainties.

I have been fortunate to work with kids whose natural curiosity and intelligence push me to be curious and intelligent too. Their unending questions, silly and brilliant ideas and zest for life fuel my own journey to lifelong learning.

I am grateful to Philippine Science High School and our mother agency, the Department of Science and Technology, for giving me a good playground to teach and to conduct research; for allowing me to go out and see the world outside of Pisay; for frequently pushing me out of my comfort zone.

This Achievement Award in Chemistry Education is a wonderful gift that I owe to the more than a thousand students I’ve had the fortune to teach. Thank you, Philippine Federation of Chemistry Societies, for this privilege and for recognizing the efforts we make at the secondary level. We may not be hard core researchers and scientists but this recognition is an affirmation that our contribution to the field is important too.

Let me thank Dr. Jose Andaya, President of the Philippine Association of Chemistry Teachers, for the surprising nomination and for the confidence in me. My heartfelt thanks also to the group of people who comprises my support system- my parents and family, and this collection of crazy, delightful, brilliant friends God blessed me with.

I dedicate this Achievement Award to my two children who are left motherless during times when I need to heed the call of duty; and to the many children in this country and beyond who are in need of meaningful education.

Thank you and God bless us all.

Janeth Morata-Fuentes is recipient of the 2017 PFCS Achievement Award for Chemistry Education (Secondary Level). She delivered this speech during the awarding ceremony in the 32nd Philippine Chemistry Congress, Asturias Hotel, Puerto Princesa City, Palawan.

She is a special science teacher at the Philippine Science High School-Eastern Visayas Campus in Palo, Leyte. She teaches Chemistry and handles Science & Technology Research. She graduated from the University of the Philippines—Diliman with a degree of Bachelor of Science in Education (Chemistry). She took her Master of Education (Teaching and Curriculum Studies) at the University of Sydney (New South Wales, Australia) where she graduated with merit. She is currently a PhD (Chemistry Education) student at the UP Open University.

The Warning on Saturated Fat: From Defective Experiments to Defective Guidelines

This article is written by Dr. Fabian Dayrit, current president of the Integrated Chemists of the Philippines and the chairman of the Asian and Pacific Coconut Community’s Scientific Advisory Committee for Health, and is in response to the recent viral advisory published by the American Heart Association (AHA) warning the public against the use of coconut oil due to its saturated fat content.

Abstract

Coconut oil has been adversely affected by the current dietary guidelines that advocate a lowering of total fat and the replacement of saturated fat with polyunsaturated fat. This recommendation has its origins in the saturated fat-cholesterol-heart disease hypothesis that Ancel Keys first proposed in 1957. This hypothesis became an official recommendation with the publication of the Dietary Guidelines for Americans in 1980 and has been adopted by many other countries and international agencies. The dietary recommendations also warn against coconut oil. Recently, the American Heart Association re-issued this warning in its 2017 Presidential Advisory. However, a critical review of the experiments that Keys conducted has revealed experimental errors and biases that cast serious doubt on the correctness of his hypothesis and the warnings against coconut oil. Further, the recommendation to decrease saturated fat recommendation effectively means an increase in unsaturated fat in the diet. The actual result has been an increase in omega-6 fats and a high omega-6 to omega-3 fat ratio. This unhealthy ratio has been linked to heart disease, the very disease that the AHA wants to target, as well as cancer and inflammatory diseases. Defective experiments have led to defective guidelines. This first paper in this series of papers will present these errors and biases and address the points raised by the AHA.

Abbreviations: AHA: American Heart Association; CHD: coronary heart disease; CVD: cardiovascular disease; HFCS: high fructose corn syrup; MCS: Minnesota Coronary Survey; PUFA: polyunsaturated fatty acid; SDHS: Sydney Diet Heart Study; SFA: saturated fatty acid

Introduction: the Dietary Guidelines

The Vital Statistics of the United States 1976 listed “diseases of heart” as the leading cause of death in the US (USDHHS, 1980). From 1980 to 2015, there were eight editions of the Dietary Guidelines for Americans which sought to address the problem of heart disease. In all eight editions of the Dietary Guidelines, there was one warning that was consistent: “Decrease overall fat intake and replace saturated fat with unsaturated fat.” However, in 2016, heart disease continued to be the leading cause of death in the US (CDC, 2016). In its 2017 Presidential Advisory, the American Heart Association continued to emphatically recommend that “lowering intake of saturated fat and replacing it with unsaturated fats, especially polyunsaturated fats, will lower the incidence of CVD (Sacks et al., 2017).

Albert Einstein famously defined insanity as: “doing the same thing over and over again and expecting different results.” This essay aims to show how the Dietary Guidelines and the AHA recommendation are examples of insanity.

The warning against “saturated fat” is virtually the same recommendation that Ancel Keys made in the 1950s. The Keys hypothesis, generally known as the saturated fat-cholesterol-heart disease hypothesis, states that saturated fats raise serum cholesterol which in turn increases the risk for heart disease. Although the saturated fats that are most often studied are animal fats, coconut oil is often included in this warning because it is a saturated fat.

This first paper will discuss the basis for the recommendations against coconut oil and saturated fat. We will review of the work of Ancel Keys which reveals several errors that invalidate his strictures against coconut oil.

Errors in the Keys experiments 

Keys committed several serious errors that cast doubt on the validity of his saturated fat-cholesterol-heart disease hypothesis with respect to coconut oil. He conducted both human feeding and observational studies. In his human feeding studies, Keys used hydrogenated coconut oil, while in his observational studies coconut oil was only a minor component of the population’s diet. Finally, Keys was never able to unambiguously prove his hypothesis and refused to acknowledge results that contradicted his hypothesis.

Keys used hydrogenated coconut oil in his human feeding studies

In 1957, Keys published two important papers, one in the Journal of Nutrition (Anderson, Keys & Grande, 1957) and the other in Lancet (Keys, Anderson, Grande, 1957) on controlled feeding studies using schizophrenic patients from the Hastings State Hospital, businessmen in Minnesota, and Japanese coalminers in Shime, Japan. These were relatively small, short-term feeding studies with the number of subjects ranging from 16 to 66. In these studies, Keys wanted to compare the effects on serum cholesterol of feeding monounsaturated and polyunsaturated fats versus saturated fats. For sources of unsaturated fats, he used corn oil, olive oil, cottonseed oil, safflower oil, and sardine oil. For sources of saturated fats, he used butterfat, margarine and hydrogenated coconut oil (HydrolÔ) in the Minnesota experiment and margarine in the Shime experiment.

The use of hydrogenated fats – margarine and Hydrol – in this feeding study casts doubt on the validity of the conclusions of this work regarding the effects of coconut oil. It was already known in the 1920s that hydrogenation of vegetable oils produced trans fats (Hilditch & Vidyarthi, 1929). In 1957, the same year when both Keys papers came out, it was reported that trans fats were deposited in various human tissues, such as adipose tissues, liver, aortic tissue, and atheroma of those who died of atherosclerosis (Johnston, Johnson, Kummerow, 1957).  In a 1961 paper on hydrogenated fats, Keys himself noted that hydrogenated oils raised serum cholesterol and triglycerides (Anderson, Grande, Keys, 1961). Therefore, the increase in serum cholesterol that Keys observed may have been due to the trans fats in margarine and hydrogenated coconut oil and this would make his conclusions invalid. The use of hydrogenated coconut oil may also have biased Keys’s judgment against coconut oil.

The Seven Countries Study was not a representative study

Keys described the evolution of the Seven Countries Study in a book that he published in 1980. Keys conducted initial studies on CHD in 1947 in Minnesota on healthy businessmen and professionals. In 1952, this study expanded to include Italy and Spain, in 1956, Japan and Finland. The aim of these studies was to identify dietary and lifestyle factors in apparently healthy middle-aged men that contributed to CHD. However, this study had two built-in limitations which would give results that are not representative. First, to ensure higher probability of successful follow-up (every 5 years), the study targeted rural populations so that 11 of the 16 cohorts studied were rural populations. For the US, since the stability of rural populations could not be assured, the American subjects selected were railroad men and to balance this effect, Italian railroad men were also selected. Second, the basis for the selection of the seven countries was not systematic but was decided by the availability of collaborators. As Keys himself stated, it was the availability of research collaborators that became the deciding factor in the selection of subject areas (Keys, 1980). It is clear that there was no scientific basis for the selection of the seven countries and these limitations should have been declared so that sweeping generalizations could be avoided.

The Seven Countries Study was begun in 1956 and ended with the publication of the 1986 paper (Keys et al., 1986). The most important conclusions from the Seven Countries Study were given as follows:

“Death rates were related positively to average percentage of dietary energy from saturated fatty acids, negatively to dietary energy percentage from monounsaturated fatty acids …. All death rates were negatively related to the ratio of monounsaturated to saturated fatty acids… Oleic acid accounted for almost all differences in monounsaturates among cohorts. All-cause and coronary heart disease death rates were low in cohorts with olive oil as the main fat.”

There are a number of important things that should be noted regarding the Seven Countries Study: First, this study cannot be claimed to be representative for all types of oils and for all groups of people. Second, the beneficial oil claimed in the Seven Countries Study was olive oil and it should be compared only to the other fats and oils that were consumed, which was mainly animal fat. Interestingly, although Japan showed very low death rates, olive oil consumption in Japan was negligible (Pitts et al., 2007). Third, this study assumed that all saturated fats have the same properties regardless of chain length. This assumption is not valid given what is known today regarding the individual properties of saturated fatty acids (this will be discussed in a succeeding article).

Coconut oil was not a significant part of the diet in the Seven Countries Study

Coconut oil was not a significant part of the diet in any of the seven countries and it was not mentioned in the 1986 Keys paper. Based on the consumption record for the year 1961, the estimated amount of animal fat consumed in Northern and Southern Europe was 67.5% and 35.7%, respectively, while for coconut oil, it was 5.9% and 1.6%. In the US, the amount of animal fat in the diet was 51% versus 3% for coconut oil (FAOSTAT, 2006; Pitts et al., 2007). Clearly, coconut oil was an insignificant part of the diet in Europe and the US so how did coconut oil get included in the health warnings on heart disease?

The Low-fat Diet and Obesity

The first official recommendation on saturated fat was contained in the first Dietary Guidelines for Americans which was jointly issued by the US Department of Agriculture and the US Department of Health and Human Services in 1980 and updated every 5 years. From the first to the eighth edition of Dietary Guidelines, the recommendation on saturated fat remained fundamentally the same: consume a low fat diet and avoid saturated fat. In the 2010 edition, the recommendation was made more specific: “consume less than 10% of calories from saturated fatty acids by replacing them with monounsaturated and polyunsaturated fatty acids.”

Cohen and co-workers (2015) conducted a comprehensive analysis of the food consumption patterns together with the body weight and body mass index of the US adult population using data from the US National Health and Nutrition Examination Survey (NHANES). They found that Americans in general have been following the nutrition advice from the Dietary Guidelines. In particular from 1971 to 2011, consumption of fats dropped from 45% to 34% of total caloric intake, but this was accompanied by an increase in carbohydrate consumption from 39% to 51%. The result was a dramatic increase in the percentage of overweight or obese Americans from 42% to 66% over the same period. It is surprising that the AHA would continue to recommend the “low-fat diet” in light of the obesity epidemic among Americans.

Keys failed to prove his Saturated Fat-Cholesterol-Heart Disease Hypothesis

Since the Seven Countries Study was an observational study, Keys wanted to do a study where he could carefully control the diet of the subjects. In 1967, Ivan Frantz, Jr. and Ancel Keys undertook a project entitled “Effect of a Dietary Change on Human Cardiovascular Disease,” also called the “Minnesota Coronary Survey” (MCS). This study was funded by the US National Heart, Lung and Blood Institute and was undertaken from 1968 to 1973. MCS was meant to be a landmark study because of the large number of subjects (n=9,423), the length of the feeding study (5 years), the high level of dietary control, and the double blind randomized design. MCS used residents in a nursing home and patients in six state mental hospitals in Minnesota. This enabled the study to carefully control and document the food that was actually consumed. This study sought to test whether replacement of saturated fat (animal fat, margarines and shortenings) with vegetable oil rich in linoleic acid (mainly corn oil) will reduce all-cause death, and CHD in particular, by lowering serum cholesterol. Coronary atherosclerosis and myocardial infarcts were also checked in 149 autopsies conducted (Ramsden et al., 2016). This study was conducted at the same time that Keys was coordinating the Seven Countries Study and would have provided powerful validation of the saturated fat-cholesterol-heart disease hypothesis.

Unfortunately, Keys did not publish the results of this study. A partial release of the results of MCS study was made in a 1989 paper in the journal Arteriosclerosis with Frantz as lead author. This paper made the modest conclusion that: “For the entire study population, no differences between the treatment (high linoleic acid group) and control (high saturated fat group) were observed for cardiovascular events, cardiovascular deaths, or total mortality.” (Frantz et al., 1989). Interestingly, although Keys was a co-proponent of the MCS study, his name did not appear as a co-author in the Arteriosclerosis paper; he was not even mentioned in the Acknowledgment.

The full data were discovered in the basement of the home of Frantz by his son, Robert, who turned them over to Ramsden and co-workers, who then analyzed and interpreted the data (O’Connor, 2016). The key results from the MCS study were reported by Ramsden and co-workers (2016) and are summarized as follows:

  • The group that consumed the high linoleic acid diet showed significant reduction in serum cholesterol compared with those on the saturated fat group.
  • However, there was no difference in mortality among the groups.
  • There was a higher risk of death in subjects who showed reduction in serum cholesterol level.
  • The main conclusions from this study are as follows: a high linoleic acid diet effectively lowers serum cholesterol but this increases the risk of CHD.

The results of the MCS study did not give the expected results and directly contradicted the conclusions of the Seven Countries Study which Keys had published in a few years earlier in 1986. This might explain why it was published in a journal of limited circulation which gave it less exposure. It is clear that a wider distribution of the results of the 1989 paper, with Keys properly included as co-author, would have been fatal to the saturated fat-cholesterol-heart disease hypothesis and to the scientific basis of Dietary Guidelines, which was going into its third edition.

The recovered MCS study is not the only example of an unreported study which had negative results. The Sydney Diet Heart Study (SDHS) was conducted from 1966 to 1973, almost at the same time as the MCS study, with the same objectives and similar study design to evaluate the effectiveness of replacing dietary saturated fat with linoleic acid for the prevention of CHD and all-cause mortality. This was a single blinded, parallel group, randomized controlled trial involving 458 men aged 30-59 years with a recent coronary event. The intervention involved replacement of dietary saturated fats (from animal fats, common margarines, and shortenings) with omega-6 linoleic acid (from safflower oil and safflower oil polyunsaturated margarine). The primary outcome was all-cause mortality and the secondary outcomes were CHD and death from heart disease. The results of this study were contrary to expectation: the unsaturated fat group had higher rates of death than the animal fat group, both in terms of all-cause mortality and CVD mortality. Similar to the recovered MCS study, the SDHS data were not reported but were recovered for analysis by Ramsden and co-workers almost 40 years after it was conducted (Ramsden et al., 2013).

In addition to the hidden MCS and SDHS studies, there are a number of published studies that contradicted the saturated heart-cholesterol-heart disease hypothesis. A six-year dietary study of 21,930 Finnish men, aged 50-69 years, concluded that there was no association between the intake of saturated fat and monounsaturated fat with the risk of coronary death (Pietinen et al., 1997). A dietary study of 80,082 women in the US Nurses’ Health Study, aged 34–59 years, with a 14-year follow-up, failed to come up with an unambiguous conclusion on the link between saturated fat and CHD (Hu et al., 1999). A study involving 58,453 Japanese men and women, aged 40-79 years, with a 14- year follow-up, gave an inverse association between SFA intake and mortality from total cardiovascular disease and concluded that replacing SFA with PUFA would have no benefit for the prevention of heart disease (Yamagishi et al., 2010).

One would think that these studies should be enough evidence to prove that the saturated fat-cholesterol-heart disease hypothesis is wrong. Unfortunately, the 2017 AHA Presidential Advisory did not cite these studies and instead went out of its way to discredit the results of the Minnesota Coronary Survey and the Sydney Diet Heart Study so that they could remove these studies from the “totality of the scientific evidence (that) satisfy rigorous criteria for causality.”

In 1981, Steven Broste, who was then a MS student at the University of Minnesota, analyzed the MCS data and addressed the difficulties that the AHA used to reject this study. These issues included withdrawals and uneven feeding periods of subjects. After making the appropriate statistical corrections, Broste still came to the conclusion that: “the experimental diet of the MCS may actually have been harmful in some way to patients who were exposed to it for at least one year” (Broste, 1981, p 85), and that “the experimental diet of the MCS, and reductions in cholesterol that resulted from the diet, were counterproductive… cholesterol reductions were generally associated with increased mortality, especially among males and older patients” (Broste, 1981, p 97).  Broste’s conclusions were consistent with those of Frantz and co-workers (1989) and Ramsden and co-workers (2016). Contrary to the claims of the AHA, the MCS results are valid: low serum cholesterol increases the risk of CHD. It is unfortunate that the AHA chose to dismiss the results of the MCS and SHDS studies as lacking in scientific rigor.

High PUFA consumption and high omega-6 to omega-3 ratio: A dietary disaster

The low-fat and low-saturated fat recommendation of the Dietary Guidelines may be the reason for rising obesity, diabetes, and other metabolic diseases among Americans. The low-fat recommendation has effectively increased the consumption of sugar and carbohydrates. Since 1980, consumption of fats fell by 11% of total caloric intake (from 45% to 34%), while consumption of carbohydrates rose by 12% (from 39% to 51%) (Cohen et al., 2015). The consumption of soybean oil, a high omega-6 polyunsaturated oil, more than doubled during the same period and now accounts for over 90% of vegetable oil consumption in the US (Index Mundi, 2016). Because soybean oil is a polyunsaturated oil, it is susceptible to the formation of free radicals, malondialdehyde, trans fats, and polymeric material during frying (Brühl, 2014).

The other major problem with the Dietary Guidelines is that it has resulted in a diet with excessive omega-6 fatty acid resulting in an average omega-6 to omega-3 ratio of about 15:1. Such a high ratio has been blamed for cardiovascular disease, cancer, and chronic inflammatory, and autoimmune diseases. The ideal omega-6 to omega-3 ratio is about 4:1 (Simopoulos 2002, 2008, 2010).

AHA should worry about the impact of too much soybean oil – not coconut oil – on the American diet. It should also rethink its support for the Dietary Guidelines.

From defective experiments to defective guidelines

Despite its widespread adoption, the saturated fat-cholesterol-heart disease hypothesis has been shown to be incorrect. Ancel Keys committed a number of errors and was unable to unambiguously demonstrate a causal link for the role of saturated fat in heart disease. The twenty-five year old, 8-edition Dietary Guidelines for Americans, which has a great influence on international guidelines, has failed to address the problem of heart disease. Defective experiments can only lead to defective guidelines, and defective guidelines can only result in poor health outcomes.

References:

Anderson JT, Grande F, Keys A (1961). Hydrogenated Fats in the Diet and Lipids in the Serum of Man. J. Nutr. 75: 388-394.

Anderson JT, Keys A, Grande F (1957). The effects of different food fats on serum cholesterol concentration in man. J Nutr. 62: 421-444.

Broste SK (1981). Lifetable Analysis of the Minnesota Coronary Survey. MS thesis, University of Minnesota.

Brühl L (2014). Fatty acid alterations in oils and fats during heating and frying. Eur. J. Lipid Sci. Technol. 116: 707-715.

[CDC] Center for Disease Control. 2016. https://www.cdc.gov/dhdsp/data_statistics/fact_sheets/docs/fs_heart_disease.pdf

[Codex] Codex Alimentarius 210-1999, amended 2015; Codex Alimentarius 33-1981, amended 2013.

Cohen E, Cragg M, deFonseka J, Hite A, Rosenberg M, Zhou B (2015). Statistical review of US macronutrient consumption data, 1965–2011: Americans have been following dietary guidelines, coincident with the rise in obesity. Nutrition 31: 727–732.

[FAOSTAT] Food and Agriculture Organisation Statistics Data. 2006. World lipid availability, Kg/capita/year, 1961. Food Balance Sheets, Rome: FAO.

Frantz Jr. ID, Dawson EA, Ashman PL, Gatewood LC, Bartsch GE, Kuba K, Elizabeth R. Brewer ER (1989). Arteriosclerosis 9:129-135.

Hilditch TP, Vidyarthi NL (1929). The products of partial hydrogenation of higher monoethylenic esters. Proc. Roy. Soc. A, 122(790): 552-563.

Hu FB, Stampfer MJ, Manson JE, Ascherio A, Colditz GA, Speizer FE, Hennekens CH, C Willett WC (1999). Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women. Am. J. Clin. Nutr. 70:1001–1008.

Index Mundi (2016). http:// www.indexmundi.com/

Keys A, Anderson JT, Grande F (1957). Prediction of serum-cholesterol responses of man to changes in fats in the diet. Lancet 959-966.

Keys A, Aravanis C, Blackburn H, Buzina R, Djordjević BS, Dontas AS, Fidanza F, Karvonen MJ, Kimura N, Menotti A, Mohacek I, Nedeljkovic S, Puddu V, Punsar S, Taylor HL, van Buchem FSP (1980). Seven Countries. A Multivariate Analysis of Death and Coronary Heart Disease. Harvard University Press, Cambridge, Massachusetts.

Keys A, Menotti A, Karvonen MJ, Aravanis C, Blackburn H, Buzina R, Djordjevic BS, Dontas AS, Fidanza F, Keys MH, Kromhout D, Nedeljkovic S, Punsar S, Seccareccia F, Toshima H (1986). The diet and 15-year death rate in the Seven Countries Study. Am. J. Epidemiol. 124(6): 903-915.

O’Connor A (2016). A Decades-Old Study, Rediscovered, Challenges Advice on Saturated Fat. New York Times, April 13, 2016. http://well.blogs.nytimes.com/2016/04/13/a-decades-old-study-rediscovered-challenges-advice-on-saturated-fat/?_r=0

Pietinen P, Ascherio A, Korhonen P, Hartman AM, Willett WC, Albanes D, Virtamo J (1997). Intake of Fatty Acids and Risk of Coronary Heart Disease in a Cohort of Finnish Men. Am. J. Epidemiol. 145(10): 876-887.

Pitts M, Dorling D, Pattie C (2007). Oil for Food: The Global Story of Edible Lipids. Journal of World-Systems Research, Volume XIII, Number 1, Pages 12-32. ISSN 1076-156X.

Ramsden CE, Zamora D, Leelarthaepin B, Majchrzak-Hong SF, Faurot KR, Suchindran CM, Ringel A, Davis JM, Hibbeln JR (2013). Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis. BMJ 2013;346:e8707.

Ramsden CE, Zamora D, Majchrzak-Hong S, R Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A, Suchindran CM, Hibbeln JR (2016). Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73). BMJ 2016;353:i1246 http://dx.doi.org/10.1136/bmj.i1246.

Sacks FM, Lichtenstein AH, Wu JHY, Appel LJ, Creager MA, Kris-Etherton PM, Miller M, Rimm EB, Rudel LL, Robinson JG, Stone NJ, Van Horn LV (2017). Dietary Fats and Cardiovascular Disease, A Presidential Advisory From the American Heart Association. Circulation 135: e1-e24.

Simopoulos AP (2002). The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 56(8): 365-79.

Simopoulos AP (2008). The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases. Exp Biol Med 233(6): 674-688.

Simopoulos AP (2010). Genetic variants in the metabolism of omega-6 and omega-3 fatty acids: their role in the determination of nutritional requirements and chronic disease risk. Exp Biol Med 235: 785–795.

[USDA] United States Department of Agriculture (2017). United States Department of Agriculture. Food Composition Databases. https://ndb.nal.usda.gov/; (downloaded: May 15, 2017).

[USDHHS] U.S. Department of Health and Human Services. 1980. Vital Statistics of the United States 1976. Volume II- Mortality. Part A. National Center for Health Statistics. Hyattsville, Maryland.

Vijayakumar M, Vasudevan DM, Sundaram KR, Krishnan S, Vaidyanathan K, Nandakumar S, Chandrasekhar R, Mathew N (2016). A randomized study of coconut oil versus sunflower oil on cardiovascular risk factors in patients with stable coronary heart disease. Ind. Heart J. 68: 498-506.

Yamagishi K, Iso H, Yatsuya H, Tanabe N, Date C, Kikuchi S, Yamamoto A, Inaba Y, Tamakoshi A, (JACC Study Group) (2010). Dietary intake of saturated fatty acids and mortality from cardiovascular disease in Japanese: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC) Study. Am. J. Clin. Nutr. 92:759-765.

2017 PFCS Achievement Awardees to be conferred in the 32nd Philippine Chemistry Congress

The Philippine Federation of Chemistry Societies (PFCS) will award five outstanding individuals in recognition of their contributions to chemistry in the upcoming 32nd Philippine Chemistry Congress.

The awards are given under four categories: Chemistry Education, Chemical Research, Chemical Industry and Service to the Chemistry Profession. These awards aim to inspire the youth to take up chemistry and to recognize the outstanding contribution of chemists toward the development of the discipline and the society.

The 2017 Achievement Awards committee is chaired by Dr. Armando M. Guidote, Jr. (PFCS) with Dr. Jose M. Andaya (PACT), Dr. Fabian M. Dayrit (ICP) and Dr. Fortunato B. Sevilla III (KKP) as committee members. Some of the Achievement Awards are co-presented by Shimadzu Philippines Corporation and United Laboratories, Inc.

The 2017 PFCS Achievement Awardees are as follows:

Janeth Morata-Fuentes (Chemistry Education, Secondary Level)

Janeth Morata-Fuentes is a special science teacher at the Philippine Science High School-Eastern Visayas Campus in Palo, Leyte. She teaches Chemistry and handles Science & Technology Research. She graduated from the University of the Philippines—Diliman with a degree of Bachelor of Science in Education (Chemistry). She took her Master of Education (Teaching and Curriculum Studies) at the University of Sydney (New South Wales, Australia) where she graduated with merit. She is currently a PhD (Chemistry Education) student at the UP Open University.

Ramon S. del Fierro, PhD (Chemistry Education, Tertiary Level)
(Co-presented with United Laboratories, Inc.)

Dr. Ramon Del Fierro is currently an Assistant Vice President for Academic Affairs and Professor of Chemistry at University of San Carlos, Cebu City. His expertise and research interests include Natural products Chemistry, Biochemistry, Chemical Toxicology, Bioassays, Chemical Education, and Educational Administration and Leadership.

Mark Valentine P. Balanay (Chemical Industry)
(Co-presented with Shimadzu Philippines Corporation)

Mark Balanay used his chemical knowledge and skills to become a leader in Philippine Sinter Corporation, a major corporation in Cagayan de Oro. He has engaged in a wide range of activities, including operation & production, analytical laboratory management, research & quality assurance, and human resource management. He is also the company’s lead auditor for ISO 14001 & ISO 9001. Mark has likewise used his skills to guide and build up the chemistry community in northern Mindanao into an active and responsive organization. This mix of experience, competencies, and commitment, including his dynamic interface with government, academe, industry, and scientific associations, makes him a well-rounded leader.

Maribel G. Nonato, PhD (Chemical Research)
(Co-presented with Shimadzu Philippines Corporation)

Dr. Maribel Nonato obtained her doctoral degree in Organic Chemistry with specialization in Natural Products Chemistry from the University of Wollongong, New South Wales, Australia in 1993. Upon her return to the University of Santo Tomas, Dr. Nonato resumed her research activities at the Research Center for the Natural Sciences (RCNS) where she pioneered research on the Phytochemistry and Biological Activities of Philippine grown species of the Genus Pandanus (Family Pandanaceae). She is currently the Vice Rector for Research and Innovation at the University of Santo Tomas (UST), first female and lay person to assume the post since September 2014. She had served the University of Santo Tomas as an administrator in different capacities: Director of Research Center for the Natural Sciences, acting Assistant to the Rector for Research and Development, Dean of the College of Science and Assistant to the Rector for Research and Innovation.

Marissa G. Noel, PhD (Service to the Chemistry Profession)

Dr. Marissa Noel has long been quietly working to the benefit of the Philippine Chemistry Community. She has been a regular member of organizing committees of the Philippine Chemistry Congress and most notably, has been an indispensable and trusted organizer to whom industry partners and exhibitors flock. She efficiently headed the Ways and Means Committee of many local and international PCCs since 2001 while capitalizing on her reputation to influence industry people, raise funds and generate income for the PCC. Likewise, she also rendered similar services to the Natural Product Society of the Philippines (NPSP). She sat on the organizing committee of several NPSP National Conferences and was the lead local organizer/host of the December 2013 conference held at DLSU. She is instrumental to the ratification of the Chemistry Law. Marissa, together with siblings Representative Victoria Isabel G. Noel and Former Representative Florencio Gabriel G. Noel, helped the Integrated Chemists of the Philippines (ICP) and the Philippine Federation of Chemistry Societies (PFCS) by liaising and lobbying for the Chemistry Profession Act in the Philippine Congress and Senate. After years of lobbying, dogged persistence and monitoring, the Chemistry Profession Act was signed into law by the Philippine President in 2015. The new Chemistry Law regulates, modernizes and protects the practice of the Chemistry profession in the Philippines.

Application Now Open for the ACS APICC 2017 Student Travel Grant

Apply for a Travel Grant (USD 450) to present at the 1st ACS Asia‐Pacific International Chapters Conference (APICC) in Jeju, South Korea, November 5‐8, 2017

The conference is organized by 10 American Chemical Society (ACS) International Chemical Sciences Chapters in the Asia‐Pacific region: Australia, Beijing, Hong Kong, India, Malaysia, Shanghai, South Korea, Southwest China, Taiwan, and Thailand. The ACS APICC 2017 Student Travel Grant, administered by the ACS Thailand Chapter, aims to encourage student participation, by supporting 5 undergraduate and 5 graduate students (USD 450 per person) to showcase their research work, and network effectively. Selection will be based on the abstract submitted and student’s financial
need.

Who can apply: Undergraduate, M.Sc. and Ph.D students

How to apply:

  • Register at the conference website (http://www.acskoreachapter.org/) and submit your research abstract
  • Submit the following along with the completed application form (https://goo.gl/forms/eDDNs1Nc13mzVPlx2):
    1. Resume
    2. Complete college transcripts
    3. Letters of recommendation from 2 professors
    4. Copy of the abstract you submitted online (http://www.acskoreachapter.org/)
  • E‐mail the required documents (1‐4) together with the application form to Dr. Siwaporn Meejoo Smith (siwaporn.smi@mahidol.edu)

Application Deadline: August 1, 2017
Results announced by August 31, 2017